|
KMID : 1177720110050010051
|
|
Journal of Alternatives to Animal Experiments
2011 Volume.5 No. 1 p.51 ~ p.55
|
|
|
The eye irritation potentials induced by chemical structure of cationic surfactants
|
|
Cho Sun-A
Bae Woo-Ri
Lee Eun-Young
Shin Kye-Ho
Kang Byung-Ha
Lee John-Hwan
Lee Tae-Ryong
Cho Jun-Cheol
An Su-Sun
|
|
|
Abstract
|
|
|
|
Although cationic surfactants can cause eye irritation at high concentration, it has some merits in hair conditioning function and has been commonly used in hair conditioning product as a main component. For these reasons, the selection and use of milder cationic surfactant is important in safety of cosmetics. With the use of the hen`s egg test-chorioallantoic membrane (HET-CAM) assay, we examined the eye irritation potential for several cationic surfactant according to chemical structure properties. The eye irritation potential of cationic surfactant was increased according to increasing number of alkyl chain, alkyl chain length. And the cationic surfactant that neutralized to methosulfate causes lower irritation than cationic surfactant of chloride. From these results, we can determine the eye irritation potentials of cationic surfactant according to chemical structure.
|
|
|
KEYWORD
|
|
|
HET-CAM, eye irritation, cationic surfactant, chemical structure, hair conditioner
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|